南京大学谢然

qiuyuye

谢然，特聘研究员，博士生导师 。2010年本科毕业于上海交通大学化学化工学院，2015年毕业于北京大学化学院化学生物学系，获博士学位（导师：陈兴 教授，研究方向为化学糖生物学）。2019年12月加入南京大学化学化工学院化学生物学学科，同时加入南京大学化学和生物医药创新研究院（ChemBIC），开始独立科研工作。


职务： 特聘研究员
联系电话： 17715259288
办公地址： 南京大学仙林校区化学楼G222
电子邮箱： ranxie@nju.edu.cn



工作经历
2015年至2019年在美国哈佛大学 (Havard University) 化学与化学生物学系从事博士后研究工作（合作导师为美国两院院士Daniel Kahne教授，研究方向为革兰氏阴性菌脂多糖的转运机理探究）。

研究方向
1) 新型非天然糖代谢标记探针的开发及应用
2) 疾病模型中的糖分析检测及生物学功能阐释
3) 基于非天然氨基酸插入技术的糖酶改造及功能调控
4) 革兰氏阴性菌脂多糖转运蛋白的体外重构及功能解析


学术成果
2023
1. Yihong Zhong, Lijia Xu, Chen Yang, Le Xu, Guyu Wang, Yuna Guo, Songtao Cheng, Xiao Tian, Changjiang Wang, Ran Xie, Xiaojian Wang, Lin Ding, Huangxian Ju (2023). Site-selected in situ polymerization for living cell surface engineering. Nature Communications, https://doi.org/10.1038/s41467-023-43161-x
2. Yi Man,# Di Lu# and Ran Xie* (2023). State-of-the-Art Imaging Tool Portray the Role of GlycoRNAs in Cancer-and Immuno-Biology. (Viewpoint). Chem. Biomed. Imaging2023, 1, 7, 667-669.,https://doi.org/10.1021/cbmi.3c00099
3. Xiaocui Zheng, Yiran Li, Tongxiao Cui, Jing Yang, Xiangfeng Meng, Haiqi Wang, Liusheng Chen, Jian He, Nan Chen, Liying Meng,* Lin Ding,*, and Ran Xie* (2023). Traceless Protein-Selective Glycan Labeling and Chemical Modification. J. Am. Chem. Soc., https://doi.org/10.1021/jacs.3c07889
4. Xiaocui Zheng, Boqiang He,  Liying Meng,* and Ran Xie* (2023). Recent Advances in Protein-Specific Glycan Imaging and Editing. ChemBioChem, https://doi.org/10.1002/cbic.202200778
5. Jing Yang,# Kefan Wang,# Shanyu Zhang, Xiaocui Zheng, Tongxiao Cui, Xian Yang, Yao Liu, Di Lu, Yuqin Wang, Xiao Tian, Panke Zhang, Shuo Hunag,* and Ran Xie* (2023). Site-Specific Introduction of Bioorthogonal Handles to Nanopores by Genetic Code Expansion. Angewandte Chemie International Edition, https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202216115

2022
1. Tongxiao Cui,# Yi Man,# Feifei Wang, Shuyang Bi, Liang Lin,* Ran Xie* (2022). Glycoenzyme Tool Development: Principles, Screening Methods, and Recent Advances. Chinese Journal of Chemistry,  https://doi.org/10.1002/cjoc.202100770
2. Wang, Feifei,# Hao Kong,# Xiangfeng Meng, Xiao Tian, Changjiang Wang, Lei Xu, Xiang Zhang, Lei Wang,* and Ran Xie* (2022). A light-initiated chemical reporter strategy for spatiotemporal labeling of biomolecules. RSC Chemical Biology, https://doi.org/10.1039/D2CB00072E
3. Anwen Mao, Yan Zhang, Guyu Wang, Tong Zhong, Xinyu Chen, Haiqi Wang, Ran Xie,* Xiaojian Wang, Lin Ding,* Huangxian Ju (2022). Aglycone sterics-selective enzymatic glycan remodeling. iScience, https://doi.org/10.1016/j.isci.2022.104578
4. Minglun Liu, Yuncong Chen,* Yan Guo, Hao Yuan, Tongxiao Cui, Shankun Yao, Suxing Jin, huanhuan Fan, Chengjun Wang, Ran Xie, Weijing He,* Zijian Guo* (2022) Golgi apparatus-targeted aggregation-induced emission luminogens for effective cancer photodynamic therapy. Nature Communications,  https://doi.org/10.1038/s41467-022-29872-7

Prior to NJU
1. Ran Xie, Rebecca J. Taylor and Daniel Kahne (2018). Outer Membrane Translocon Communicates with Inner Membrane ATPase To Stop Lipopolysaccharide Transport. J. Am. Chem. Soc., 140 (40), 12691-12694.
2. Yuting Sun, Senlian Hong, Ran Xie, Rongbing Huang, Ruoxing Lei, Bo Cheng, Deen Sun, Yifei Du, Corwin Nycholat, James Paulson and Xing Chen (2018). Mechanistic Investigation and Multiplexing of Liposome-Assisted Metabolic Glycan Labeling. J. Am. Chem. Soc., 140 (10), 3592–3602.
3. David J. Sherman*, Ran Xie*, Rebecca J. Taylor*, Alex H. George*, Suguru Okuda*, Peter J. Foster*, Daniel J. Needleman and Daniel Kahne (2018). Lipopolysaccharide is transported to the cell surface by a membrane-to-membrane protein bridge. Science. 359 (6377), 798-801. *Authors contributed equally.
4. Yifei Du, Ran Xie, Yuting Sun, Xinqi Fan and Xing Chen (2017). Liposome-assisted metabolic glycan labeling with cell and tissue selectivity. Meth. in Enzymol., 598:321-353.
5. Eileen Moison, Ran Xie, Ge Zhang, Matthew D. Lebar, Timothy C. Meredith, and Daniel Kahne (2017). A Fluorescent probe distinguishes between inhibition of early and late steps of lipopolysaccharide biogenesis in whole cells. ACS Chem. Biol.,12 (4), 928-932.
6. Gong Zhang, Jie Li, Ran Xie, Xinyuan Fan, Yanjun Liu, Siqi Zheng, Yun Ge and Peng Chen (2016). Bioorthogonal chemical activation of kinases in living systems. ACS Cent. Sci., 2(5), 325-331.
7. Ran Xie, Lu Dong, Rui Hua, Chen Zhang and Xing Chen (2016). In vivo metabolic labeling of sialoglycans in the mouse brain by using a liposome-assisted bioorthogonal reporter strategy. Proc. Natl. Acad. Sci. U.S.A., 113(19), 5173-5178.
8. Bo Cheng, Ran Xie, Lu Dong and Xing Chen (2016). Metabolic remodeling of cell-surface sialic acids: principles, applications, and recent advances. ChemBioChem, 17(1), 11-27.
9. Liang Lin, Ling Liu, Ran Xie, Bing Zhao, Wei Lin, Minlong Shi, Ye-Guang Chen, Timothy A. Springer and Xing Chen (2015). Carbon nanotube-assisted optical activation of TGF-β signaling by near-infrared light. Nat. Nanotech., 10, 465-471.
10. Ran Xie, Lu Dong, Rongbing Huang, Senlian Hong, Ruoxing Lei and Xing Chen (2014). Targeted imaging of tumor-associated glycans in living animals. Angew. Chem. Int. Ed., 53(51), 14082-14086.
11. Ran Xie, Senlian Hong and Xing Chen. (2013). Cell-selective metabolic labeling of biomolecules with bioorthogonal functionalities. Curr. Opin. Chem. Biol. 17(5), 747-752.
12. Ran Xie, Senlian Hong, Lianshun Feng, Jie Rong and Xing Chen. (2012). Cell-selective metabolic glycan labeling based on ligand-targeted liposomes. J. Am. Chem. Soc., 134(24), 9914-9917.
13. Sara H. Rouhanifard*, Ran Xie*, Guoxin Zhang, Xiaoming Sun, Xing Chen and Peng Wu. (2012). Detection and isolation of dendritic cells using Lewis X-functionalized magnetic nanoparticles. Biomacromolecules, 13(10), 3039-3045. *Authors contributed equally.
14. Li Lin, Ran Xie, Shaoai Xie, Nenghu Fang. (2010). Separation and quantitative analysis of microcystins in water using micro-column HILIC. Research and Exploration in Laboratory, 29(11), 203-205.
15. Ran Xie, Ziming Zhao, Xiaorong Dang. (2010). Progress in research of polyurethane/carbon nanotubes composites. China Synthetic Rubber Industry, 33(3), 238-243.

著作：
《中国学科发展战略·化学生物学》，科学出版社，ISBN 978-7-03-043399-2