南方科技大学化学系何振宇

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何振宇，南方科技大学化学系副教授，Grubbs 研究院双聘教授，广东省突出贡献人员专业技术资格有机化学研究员，广东省高校化学类专业指导委员会委员，国家“青年##计划”入选者，马萨诸塞州理工学院(MIT)博士后，在交叉氢烯基化、N-杂环卡宾Ni(II)H催化剂、催化合成支链和偕二取代烯烃、 N-杂环卡宾-过渡金属不对称催化的远程电子效应技术上建立了比较良好的国际声誉，是我国乃至全世界目前在“NHC-Ni” 和“Hydroalkenylation” 领域中最优秀的化学家之一，他积极申请各种研究经费，紧追国际前沿，科技创新能力和组织管理效果情况良好。论文获亮点报道总计>30次，获7项国际奖项(ACS, RSC, Thieme, ACP颁发)，常应邀作国际研讨会报告(超过35次海外邀请讲座和演讲，如: 入选中国-意大利有机化学双边研讨会的10人代表团)和撰写综述(Prof. Scott Miller, Yale & Dieter Enders, RWTH)，他已通过国内外专家和学术委员会评估并获得了tenure， 并已被邀请为北海道大学短期兼职讲师。是一个具有明确发展目标和动力为社会做出贡献的青年研究学者。

何振宇

副教授

化学系

0755-88018318

jasonhcy@sustc.edu.cn

研究方向

金属有机催化应用研究

Dr. Chun-Yu Ho received his Ph.D. in 2005under the supervision of Prof. Dan Yang in The University of Hong Kong fororganocatalytic asymmetric epoxidation. After pursing post-doctoral researchduring 2005-07 with Prof. Timothy F. Jamison in MIT for transition metalcatalysis, he started his independent career at The Chinese University of HongKong (CUHK) as a Research Assistant Professor at the end of 2007. Now he isAssociate Professor in South University of Science and Technology of China(SUSTC) in 2013 and Honorary AP of CUHK. He is the recipient of The CroucherFoundation Fellowship of Hong Kong, Asian Core Program Lectureship Award fromboth Japan in 2010 and Singapore in 2011, Thousand Young Talents Program Awardfrom the Chinese central government in 2012, recognized as Overseas High-CaliberPersonnel from Shenzhen in 2013, and awarded ACS Excellence in ScienceSymposium: The Journal of Organic Chemistry and Organic Letters Best Poster in2013.

2005-07 The Croucher Foundation FellowshipAward
2010-11 The Asian Core Program Lectureship Award (from Japan)
2011-12 The Asian Core Program Lectureship Award (from Singapore)
2012 Publication honored in RSC Chem. Commun. 2012 Emerging Investigator Issue
2012 Thousand Young Talents Program Awardee (from Chinese Central Government)
青年##计划
2012 One of the three invited oversea lecturers in 3rd Symposium of MolecularActivation
Directed toward Straightforward Synthesis, at Hanamaki, Iwate (MEXT, Japan)
2012 Adjunct AP at South University of Science and Technology of China
2013 Adjunct AP at The Chinese University of Hong Kong
2013 Editorial Member of Natural Products Chemistry & Research Journal
2013 Recognized as Overseas High-Caliber Personnel (Peacock Program Awardeefrom
Shenzhen Government) 深圳市孔雀计划 B 类人员
2013 Presentation in ISORM, a Celebration in Honor of Grubbs, Houk, Schleyer& Truhlar
2013 ACS Excellence in Science Symposium: The Journal of Organic Chemistry andOrganic
Letters Best Poster Award
2014 Invited Contribution in Synlett Special Issue:
Catalysis with Sustainable Metals (1 of 18 papers)
2014 Invited Contribution in J. Org. Chem. Special Issue:
Mechanisms in Metal-Based Organic Chemistry (1 of 37 papers from 14 countries)
2015 Paper recognized as very important paper in the area of N-HeterocyclicCarbene (VIP)
and Front Cover Story in Angew. Chem. Int. Ed.

A/ US Non-Provisional Patent granted orfiled (As the sole inventor):
1. Ho, C.-Y. US8354554B2 “Process for Preparing Organometalloids”
2. Ho, C.-Y. US8383873B2 “Terminal 1,1-Disubstituted Olefin, Methods of Making & Using
Thereof”
3. Ho, C.-Y. US regular patent filed, application number: 13/415304, titleremains confidential
4. Ho, C.-Y. PCT filed, application number: PCT/CN2014/082861, “Process forPreparing
Branched Allyl Compounds”
5. Ho, C.-Y. PCT filed, application number: PCT/CN2015/071187, title remainsconfidential
B/ Invited Review (As corresponding author):
1. “NHC-Ni-H Reactions with Simple Olefins: Advances inHydroalkenylation, Polymerization, and
Ionic Liquid Synthesis.”
Ho, C.-Y.*; He, L.; Chan, C.-W. Synlett 2011, SynPacts issue, 1649.
2. “Catalytic Addition of Simple Alkenes to Carbonyl Compounds UsingGroup 10 Metals”
Ho, C.-Y.*; Schleicher, K. D.; Chan, C.-W.; Jamison, T. F.* Synlett 2009, 2565.
C/ Book Chapter:
1. “NHC-Ni Hydride Catalyzed Terminal Disubstituted Alkene Synthesis”
Ho, C.-Y.*; He, L. ISBN 978-3-8465-0051-4, 88pgs.
2. “Introduction to General, Organic and Biological Chemistry” GlobalEdition
D/ Paper (Since 2005):
a/ Catalysis having C-C Bond Formation
1. “Catalytic Asymmetric Hydroalkenylation of Vinylarenes: ElectronicEffects of Substrates and
Chiral N-Heterocyclic Carbene Ligands”
Ho, C.-Y.*; Chan, C.-W.; He, L. Angew. Chem. Int. Ed. 2015, 54, 4512.
Highlighted thrice:
Featured as Front Cover & VIP (Very Important Paper),
in Angew. Chem. Int. Ed. 2015, 54 (15), 4403.
in ChemCatChem 2015, 7, 1639 by Prof. Gerhard Hilt &
in X-Mol on 2015-04-17
2. “Substituted 1,3-cyclohexadiene synthesis by NHC-Nickel(0) catalyzed[2+2+2] cycloaddition of
1,n-Enyne”
Zhao, J.-P.; Chan, S.-C.; Ho, C.-Y.* Tetrahedron 2015, 71, 4426.
Invited Special Symposium-in-Print: Progress in organic synthesis: New reactions,
strategies and targets.
3. “Medium-Sized Heterocycle Synthesis by the Use of Synergistic Effectsof Ni-NHC and γ
Coordination in Cycloisomerization.”
Ho, C.-Y.*; He, L. J. Org. Chem. 2014, 79, 11873.
Invited Special Issue:
(1 of 37 from over 14 countries)
Highlighted twice:
SynFacts 2014, 10, 913 (by Prof. V. Snieckus)
Organic Chemistry Highlights, 2015, (by Prof. D. F. Taber)
“C-O Ring Construction”.
4. “Nitrate-Enhanced NHC-NiH Catalyzed Tail-to-Tail Vinyl EtherDimerization.”
He, L.; Ho, C.-Y.* Synlett 2014, 25, 2738.
Invited Special Issue: Catalysis with Sustainable Metals. (1 of 18 papers)
5. “Shuffle off the Classic β-Si Elimination byNi-NHC Cooperation:
Implication for C-C Forming Reactions Involving Ni-Alkyl-β-Silanes.”
Ho, C.-Y.*; He, L. Chem. Commun. 2012, 48, 1481.
Honored in Emerging Investigator Issue (1 of 71 papers in the year)
Has been recommended on PubMed advanced by Novo Nordisk®
6. “Catalytic Intermolecular Tail-to-Tail Hydroalkenylation of Styreneswith alpha Olefins:
Regioselective Migratory Insertion Controlled by a Nickel/N-HeterocyclicCarbene.”
Ho, C.-Y.*; He, L. Angew. Chem. Int. Ed. 2010, 49, 9182.
Highlighted thrice:
SynForm 2011, issue 2, A15-16 & as Cover (by Prof. M. Zanda);
SynFacts 2011, issue 3, 310 (by Prof. P. Knochel);
Organic Chemistry Highlights, 2011 (by Prof. D. F. Taber)
“Functionalization & Homologation of Alkenes”.
7. “Cyanative Alkene-Aldehyde Coupling: Ni(0)-NHC-Et2AlCN MediatedChromanols Synthesis with High cis-Selectivity at room temperature.” Ho, C.-Y.*Chem. Commun. 2010, 46, 466.
8. “Nitrile assisted, Bronsted acid catalyzed regio and stereoselectivediarylphosphonylation of allyl silyl ethers.”
Ho, C.-Y.*; Chan, C.-W.; Wo, S.-K.; Zuo, Z.; Chan, L.-Y. Org. Biomol. Chem.2010, 8, 3480.
9. “Alpha Olefins as Alkenylmetal Equivalents in Catalytic ConjugateAddition Reactions.”
Ho, C.-Y.; Ohmiya, H.; Jamison, T. F.* Angew. Chem. Int. Ed. 2008, 47, 1893.
10. “Highly Selective Coupling of Alkenes and Aldehydes Catalyzed by NHC–Ni–P(OPh)3:Synergy
Between a Strong σ-Donor and a Strong π-Acceptor.”( Hot Paper)
Ho, C.-Y.; Jamison, T. F.* Angew. Chem. Int. Ed. 2007, 46, 782.
11. “Nickel-Catalyzed Coupling of Alkenes, Aldehydes, and SilylTriflates.”
Ng, S.-S.; Ho, C.-Y.; Jamison, T. F.* J. Am. Chem. Soc. 2006, 128, 11513.
12. “Nickel-Catalyzed, Carbonyl-Ene-Type Reactions: Selective for AlphaOlefins and More Efficient
with Electron-Rich Aldehydes.”
Ho, C.-Y.; Ng, S.-S.; Jamison, T. F.* J. Am. Chem. Soc. 2006, 128, 5326.
b/ Catalysis having C-Heteroatom Bond Formation
1. “Highly Chemoselective Reductive Amination of Carbonyl CompoundsPromoted by
InCl3/Et3SiH/MeOH System.”
Lee, O.-Y.; Law, K.-L.; Ho, C.-Y.; Yang, D.* J. Org. Chem. 2008, 73, 8829.
2. “Fluorinated Chiral Secondary Amines as Catalysts for Epoxidation ofOlefins with Oxone.”
Ho, C.-Y.; Chen, Y.-C.; Wong, M.-K.; Yang, D.* J. Org. Chem. 2005, 70, 898.
c/ Collaborative Pharmaceutical Research Papers Published:
1. "Synthesis, biological activity, and biopharmaceutical characterizationof tacrine dimers as
acetylcholinesterase inhibitors."
Qian, S.; He, L.; Mak, M.; Han, Y.; Ho, C.-Y.*; Zuo, Z.* Int. J. Pharmaceutics,2014, 477, 442.
2. "In Vitro Anti-acetylcholinesterase Activities and Permeabilities ofNovel Potential Anti-Alzheimer's Agents".
Qian, S.; Mak, M.; He, L.; Ho, C.-Y.*; Han, Y.*; Zuo, Z.*
Paper presented in the 9th International ISSX Meeting, organized byInternational Society for the Study of Xenobiotics, 1 pgs. Istanbul, Turkey, 2010.09.04.
3. "Structure-activity and structure-permeability relationships of novelanti-Alzheimer’s agents tacrine dimers".
Qian, S.; He, L.; Mak, M.; Ho, C.-Y.*; Han, Y.*; Zuo, Z.* Paper presented inthe 2011 AAPS Annual Meeting and Exposition, organized by The AmericanAssociation of Pharmaceutical Scientists, 1 pgs. Washington, DC, USA,2011.10.26.
4. "Development of LC/MS/MS method for determination of a novel tacrinedimer HLS-3 in rat plasma and its application to pharmacokinetic study".
Qian, S.; He, L.; Wo, S-K.; Mak, M.; Han, Y.*; Ho, C-Y.*; Zuo, Z.* Paperpresented in the 2012 AAPS Annual Meeting and Exposition, organized by TheAmerican Association of Pharmaceutical Scientists, USA, 2012.10.14.